Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells
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چکیده
منابع مشابه
Ectopic erythema migrans in an adolescent with a skin disorder.
Red and white circular lesions of the buccal and labial mucosa were observed in an adolescent. Periodically, these nontender patches would resolve and move to other oral sites. Detection of ectopic erythema migrans aided in the diagnosis of a bothersome skin condition.
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This manuscript describes the typical presentation of erythema migrans caused by tick bite. The purposes of this article are (i) to encourage physicians to observe patients with tick bite carefully since it may cause fatal encephalitis, and (ii) to facilitate physicians, especially in endemic areas, to consider tick-borne encephalitis virus as one of the causes of encephalitis.
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An 18-year-old man with developmental disability presented with a circular, erythematous red rash (pictured) with central clearing that measured 5 cm in diameter. The rash developed on his abdomen 9 days after his father removed a small tick from the area where the rash appeared. His parents were unaware of how long the tick had been attached. The patient had several recent outdoor exposures wh...
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Memory B cells are generated in germinal centers (GC) and contribute to serological immunity by rapidly differentiating into plasma cells. Human memory B cells can be identified by the expression of CD27. These cells exhibit more rapid responses than naive (CD27-) B cells following stimulation in vitro, consistent with the heightened kinetics of secondary responses in vivo. CD27+ B cells expres...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2021
ISSN: 2379-3708
DOI: 10.1172/jci.insight.148035